tyrS [2017-07-20 13:03:26]

tyrosyl-tRNA synthetase (major)

Locus: BSU29670

Isoelectric point: 5.21

Molecular weight: 47.57 kDa

Protein length: 422 aa

Gene length: 1266 bp

Function: translation

Product: tyrosyl-tRNA synthetase (major)

Essential: yes

E.C.: 6.1.1.1

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
• Groups of genes → Essential genes

Gene

Coordinates: 3,036,603 → 3,037,871

Phenotypes of a mutant

• essential PubMed
• the gene can be deleted, but the mutant acquires suppressors in dtrR to allow expression of tyrZ PubMed
• a tyrS tyrZ double mutant is not viable PubMed

The protein

Structure

• 3TS1 (complex with tyrosyl adenylate intermediate, Geobacillus stearothermophilus)
• 1JH3 (C-terminal domain, Geobacillus stearothermophilus)
• 1N53 (the T-box antiterminator RNA) PubMed

Additional information

• belongs to the 100 most abundant proteins PubMed

Expression and Regulation

Operons

• Genes: ytzK-tyrS
  Description: PubMed

  Regulation

  • the T-box RNA is degraded by RNase Y PubMed

• Genes: acsA-ytzK-tyrS
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon
  • CodY: repression, PubMed, in CodY regulon

  Regulation

  • repressed by glucose (4.5-fold) (CcpA) PubMed

• Genes: tyrS
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • T-box: anti-termination, in T-box

  Regulation

  • induced by tyrosine limitation (T-box) PubMed
  • the T-box RNA is degraded by RNase Y PubMed

References

Reviews

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Original publications

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